Robert Page will announce his 26-man squad for Wales’ first World Cup in 64 years when he returns to Tylorstown in the Rhondda valley on Wednesday.
Manager Page will reveal the squad at a special event in his hometown shortly after 19:00 GMT, live on BBC One Wales.
Captain Gareth Bale and midfielder Joe Allen are among the fitness concerns, while forward Rubin Colwill and Tyler Roberts are recovering from injuries.
Wales face the United States in their opening World Cup match on 21 November.
They are joined in Group B by Iran and England, who name their squad on Thursday.
Page has previously indicated that he has already decided on the majority of the 26 players he will be taking with him to Qatar, but there will still be a nervous wait for many on Wednesday night.
The squad will be announced in front of an audience at Tylorstown Welfare Hall, the last remaining miners welfare hall in the Rhondda Fach valley and a place where Page spent much of his childhood.
As well as contemplating his final few choices, the former Wales centre-back will have his fingers crossed that all his players emerge unscathed from the remaining fixtures before club football pauses for the start of the World Cup.
It is virtually certain that Bale will captain Wales in Qatar but the 33-year-old has said he is “not 100%” fit.
That is despite his crucial late goal in Los Angeles FC’s MLS Cup final triumph over Philadelphia Union last weekend.
Bale has been integral to Wales’ recent success – they have qualified for three of the past four major tournaments having reached only one before that – and will be their talisman once more at the World Cup.
However, the former Real Madrid player has made just two starts – plus 11 substitute appearances – for LAFC since joining the American side in June.