Side Effects of Dialysis

Both haemodialysis and peritoneal dialysis cause side effects. This is because of the way dialysis is carried out and the fact it can only partially compensate for the loss of kidney function.


Fatigue, where you feel tired and exhausted all the time, is a common side effect in people who use either form of dialysis on a long-term basis. Fatigue is thought to be caused by a combination of the:

  • loss of normal kidney functionRisks and side effects of dialysis
  • Effects dialysis can have on the body
  • Dietary restrictions associated with dialysis
  • Overall stress and anxiety that many people with kidney failure experience

You may want to talk to your dietitian to see if your diet can be adjusted to increase your energy levels.

Regular exercise may also help. If you are fatigued and on dialysis, starting a programme of regular exercise can be difficult. But if you persevere, you will probably find that exercising becomes easier with time.

Low-to-moderate aerobic exercise such as cycling, running, walking or swimming is best. Your GP or dialysis care team will be able to advise you about the type of exercise most suitable for you.

Side effects of haemodialysis

Low blood pressure

Low blood pressure (hypotension) is one of the most common side effects of haemodialysis. It can be caused by the drop in fluid levels during dialysis. Low blood pressure can cause nausea and dizziness.

The best way to minimise these symptoms of low blood pressure is to keep to your daily fluid intake recommendations. If your symptoms persist, you should consult your dialysis care team because the amount of fluid used during dialysis may need to be adjusted.


People receiving haemodialysis are at increased risk of developing sepsis (blood poisoning). This is where bacteria enter the body and spread through the blood, potentially leading to multiple organ failure.

Warning symptoms include dizziness and a high temperature (fever) of 38C (100.4F) or above. If you develop sepsis, you’ll need to be admitted to hospital and treated with injections of antibiotics.

Muscle cramps

During haemodialysis, some people experience muscle cramps, usually in their lower legs. This is thought to be caused by the muscles reacting to the fluid loss that occurs during haemodialysis.

Consult your dialysis care team if you have muscle cramps that become particularly painful. Medication may be available to help you cope with the symptoms.

Itchy skin

Many people receiving haemodialysis experience itchy skin, caused by a build-up of minerals in the body between dialysis sessions. Tell your care team if your skin becomes very itchy. They may recommend creams to soothe and moisturise your skin.

Other side effects

Other side effects of haemodialysis can include:

  • Difficulties falling asleep (insomnia) or staying asleep
  • Bone and Joint Pain
  • Loss of Libido (sex drive) and Erectile Dysfunction
  • Dry Mouth
  • Anxiety

Side effects of peritoneal dialysis


A common side effect of peritoneal dialysis is bacterial infection of the peritoneum (peritonitis). Peritonitis can occur if the dialysis equipment is not kept clean. If there are bacteria on the equipment, they can spread to the peritoneum (thin layer of tissue that lines the inside of the abdomen).

The most effective way to prevent peritonitis is to keep your dialysis equipment clean. You’ll be given training in how to do this.

Signs and symptoms of peritonitis can include:

  • Abdominal Pain
  • A high temperature (fever) of 38C (100.4F) or above
  • Feeling and being sick
  • Experiencing chills
  • The used dialysis fluid becoming cloudy

Contact your dialysis unit immediately if you develop these symptoms. Peritonitis is treated with injections of antibiotics. If the infection is severe or keeps coming back, you may need to switch to haemodialysis.


People receiving peritoneal dialysis are at increased risk of developing a hernia because holding fluid inside the peritoneal cavity for many hours puts a strain on the muscles of the abdomen.

The main symptom of a hernia is the appearance of a lump in your abdomen. The lump may be painless and may only be discovered during a check-up. In some people, certain activities, such as bending over or coughing, can cause the lump to appear.

Surgery is usually needed to repair a hernia. During surgery, the surgeon will place the protruding tissue back inside your abdominal wall. The muscles of the abdominal wall may also be strengthened using a synthetic mesh.

Weight gain

The dialysate fluid used during peritoneal dialysis contains sugar molecules, some of which are absorbed into your body. This can increase your daily calorie consumption by up to several hundred calories a day.

If you don’t compensate for these extra calories by reducing the amount of calories you eat and by taking regular exercise, it’s likely you will gain weight.

If you’re concerned that you are gaining too much weight, you should talk to your dialysis team who can recommend a diet and exercise plan.

Avoid following fad diets that claim to be able to help you lose a lot of weight quickly. This type of extreme dieting could upset your body’s chemistry and make you feel very ill.

Read More ON:
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Causes of Kidney Infection
Treating Kidney Infection
Diagnosing Kidney Infection
Chronic Kidney Disease
Symptoms of Chronic Kidney Disease
Diagnosing Chronic Kidney Disease
Treating Chronic Kidney Disease
Causes of Chronic kidney Disease
Kidney Cancer
Diagnosing Kidney Cancer
Treating Kidney Cancer
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Symptoms of Kidney Stones
Causes of Kidney Stones
Treating Kidney Stones
Kidney Transplant

Source: NHS UK